TOUPANCE Bruno

Summary

• 2001-present 
  Assistant Professor, Eco-Anthropologie (EA), Université Paris Cité, CNRS, Muséum national d’Histoire naturelle, Paris, France
• 2017 
  Habilitation à Diriger des Recherches (HDR), Université Paris Diderot, Paris, France
• 1999-2001 
  Postdoctoral researcher with Evelyne Heyer at Laboratoire Anthropologie Biologique, Musée de l’Homme, MNHN, Paris, France
• 1997-1999 
  Teaching and Research Temporary Attaché (ATER), Université Paris-Sud 11, Orsay, France
• 1994-1998 
  PhD thesis with Bernard Godelle and Pierre-Henri Gouyon at Laboratoire Ecologie, Systématique et Evolution, Université Paris-Sud 11, Orsay, France
• 1993-1994 
  Scientifique du contingent at Laboratoire Bioénergétique, CEA, Saclay, France
• 1990-1993 
  Institut National Agronomique Paris-Grignon (INA-PG - AgroParisTech), Paris, France

Teaching

• Probability
• Biostatistics
• Population genetics, Population genomics
• Molecular evolution
• Molecular phylogeny
• Programming: bash, R

Students

PhD Students

• 2023-present: Charlotte Antoine (co-supervision with Florent Détroit, Romain Laurent)
• 2012-2015: Elise A. Lucotte
• 2010-2013: Romain Laurent (co-supervision with Raphaëlle Chaix)
• 2008-2011: Jean-Tristan Brandenburg (co-supervision with Frédéric Austerlitz)

Software (Teaching)

• Genetic-Drift_Shiny: R shiny application for genetic drift simulations.
• TreeToy_Clone_Shiny: R shiny application for coalescence tree simulations.

Publications (2019-2024)

• Laurent R*, Gineau L*, Utge J, Lafosse S, Phoeung CL, Hegay T, Olaso R, Boland A, Deleuze JF, Toupance B, Heyer E, Leutenegger AL, Chaix R (2024) Measuring the efficiency of purging by non-random mating in human populations. Mol-Biol-Evol 41: msae094 - doi:10.1093/molbev/msae094 - pmid:38839045
• Guyon L, Guez J, Toupance B, Heyer E, Chaix R (2024) Patrilineal segmentary systems provide a peaceful explanation for the post-Neolithic Y-chromosome bottleneck. Nat-Commun 15: 3243 - doi:10.1038/s41467-024-47618-5 - pmid:38658560
• Guez J, Achaz G, Bienvenu F, Cury J, Toupance B, Heyer É, Jay F, Austerlitz F (2023) Cultural transmission of reproductive success impacts genomic diversity, coalescent tree topologies, and demographic inferences. Genetics 223: iyad007- doi:10.1093/genetics/iyad007 - pmid:36786657
• Lucotte EA, Albiñana C, Laurent R, Bhérer C, Genome of the Netherland Consortium, Bataillon T*, Toupance B* (2022) Detection of sexually antagonistic transmission distortions in trio datasets. Evol-Lett 6: 203-2016 - doi:10.1002/evl3.271 - pmid:35386833
• Fortes-Lima CA, Laurent R, Thouzeau V, Toupance B, Verdu P (2021) Complex genetic admixture histories reconstructed with Approximate Bayesian Computation. Mol-Ecol-Resour 21: 1098-1117 - doi:10.1111/1755-0998.13325 - pmid:33452723
• Chaix R, Ly G, Laurent R, Lafosse S, Toupance B, Monidarin C, Evrard O, Bourdier F, Pavard S (2020) Structures sociales et structures génétiques dans les populations humaines. Bull-Mem-Soc-Anthropol-Paris 32: 18-23 - doi:10.3166/bmsap-2020-0071
• Ly G, Laurent R, Lafosse S, Monidarin C, Diffloth G, Bourdier F, Evrard O, Toupance B, Pavard S, Chaix R (2019) From matrimonial practices to genetic diversity in Southeast Asian populations: the signature of the matrilineal puzzle. Philos-Trans-R-Soc-Lond-B-Biol-Sci 374: 20180434 - doi:10.1098/rstb.2018.0434 - pmid:31303171
• Dandine-Roulland C, Laurent R, Dall’Ara I, Toupance B, Chaix R (2019) Genomic evidence for MHC disassortative mating in humans. Proc-Biol-Sci 286: 20182664 - doi:10.1098/rspb.2018.2664 - pmid:30890093

Publications (1995-2018)

• Ly G, Alard B, Laurent R, Lafosse S, Toupance B, Monidarin C, Diffloth G, Bourdier F, Evrard O, Pavard S, Chaix R (2018) Residence rule flexibility and descent groups dynamics shape uniparental genetic diversities in South East Asia. Am-J-Phys-Anthropol 165: 480-491 - doi:10.1002/ajpa.23374 - pmid:29359511
• Lucotte EA, Laurent R, Heyer E, Ségurel L*, Toupance B* (2016) Detection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection. Genome-Biol-Evol 8: 1489-1500 - doi:10.1093/gbe/evw090 - pmid:27189992 - Publication faisant partie de la sélection d’articles de la catégorie « Inferential Methods » publiés par la revue Genome-Biol-Evol au cours ces 10 dernières années : https://academic.oup.com/smbejournals/pages/inferential-methods-gbe
• Heyer E, Brandenburg JT, Leonardi M, Toupance B, Balaresque P, Hegay T, Aldashev A, Austerlitz F (2015) Patrilineal populations show more male transmission of reproductive success than cognatic populations in Central Asia, which reduces their genetic diversity. Am-J-Phys-Anthropol 157: 537-543 - doi:10.1002/ajpa.22739 - pmid:25821184
• Enaud L, Hadchouel A, Coulomb A, Berteloot L, Lacaille F, Boccon-Gibod L, Boulay V, Darcel F, Griese M, Linard M, Louha M, Renouil M, Rivière JP, Toupance B, Verkarre V, Delacourt C, de Blic J (2014) Pulmonary alveolar proteinosis in children on La Réunion Island: a new inherited disorder? Orphanet-J-Rare-Dis 9: 85 - doi:10.1186/1750-1172-9-85 - pmid:24927752
• Ségurel L, Austerlitz F, Toupance B, Gautier M, Kelley JL, Pasquet P, Lonjou C, Georges M, Voisin S, Cruaud C, Couloux A, Hegay T, Aldashev A, Vitalis R, Heyer E (2013) Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia. Eur-J-Hum-Genet 21: 1146-1151 - doi:10.1038/ejhg.2012.295 - pmid:23340510
• Brandenburg JT, Austerlitz F*, Toupance B* (2012) Impact of fertility transmission and other sociodemographic factors on reproductive success and coalescent trees. Genet-Res-Camb 94: 121-131 - doi:10.1017/S0016672312000298 - pmid:22647505
• Laurent R, Toupance B, Chaix R (2012) Non-random mate choice in humans: insights from a genome scan. Mol-Ecol 21: 587-596 - doi:10.1111/j.1365-294X.2011.05376.x - pmid:22121833
• Manni F, Toupance B (2010) Autochthony and HLA Frequencies in the Netherlands: When Surnames are Useless Markers. Hum-Biol 82: 457-467 - doi:10.3378/027.082.0407 - pmid:21082912
• Robert A, Toupance B, Tremblay M, Heyer E (2009) Impact of inbreeding on fertility in a pre-industrial population. Eur-J-Hum-Genet 17: 673-681 - doi:10.1038/ejhg.2008.237 - pmid:19092776
• Manni F, Heeringa W, Toupance B, Nerbonne J (2008) Do surname differences mirror dialect variation? Hum-Biol 80: 41-64 - doi:10.3378/1534-6617(2008)80[41:DSDMDV]2.0.CO;2 - pmid:18505044
• Gagnon A, Toupance B, Tremblay M, Beise J, Heyer E (2006) Transmission of migration propensity increases genetic divergence between populations. Am-J-Phys-Anthropol 129: 630-636 - doi:10.1002/ajpa.20330 - pmid:16342261
• Yotova V, Labuda D, Zietkiewicz E, Gehl D, Lovell A, Lefebvre JF, Bourgeois S, Lemieux-Blanchard E, Labuda M, Vézina H, Houde L, Tremblay M, Toupance B, Heyer E, Hudson TJ, Laberge C (2005) Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec. Hum-Genet 117: 177-187 - doi:10.1007/s00439-005-1298-8 - pmid:15883838
• Manni F, Toupance B, Sabbagh A, Heyer E (2005) New method for surname studies of ancient patrilineal population structures, and possible application to improvement of Y-chromosome sampling. Am-J-Phys-Anthropol 126: 214-228 - doi:10.1002/ajpa.10429 - pmid:15386234
• Balaresque P, Toupance B, Quintana-Murci L, Crouau-Roy B, Heyer E (2004) Sex-specific selection on the human X chromosome? Genet-Res 83: 169-176 - doi:10.1017/S0016672304006858 - pmid:15462410
• Balaresque P, Toupance B, Heyer E, Crouau-Roy B (2003) Evolutionary dynamics of duplicated microsatellites shared by sex chromosomes. J-Mol-Evol 57: S128-S137 - doi:10.1007/s00239-003-0018-z - pmid:15008409
• Heyer E, Toupance B, Perri C, De Vito O, Foncin JF, Cecilia Bruni A (2003) Manic depressive illness in a founder population. Eur-J-Hum-Genet 11: 597-602 - doi:10.1038/sj.ejhg.5201001 - pmid:12891380
• Gagnon A, Toupance B (2002) Testing isonymy with paternal and maternal lineages in the early Québec population: the impact of polyphyletism and demographic differentials. Am-J-Phys-Anthropol 117: 334-341 - doi:10.1002/ajpa.10059 - pmid:11920369
• Le Thierry d’Ennequin M, Panaud O, Toupance B, Sarr A (2000) Assessment of genetic relationships between Setaria italica and its wild relative S. viridis using AFLP markers. Theor-Appl-Genet 100: 1061-1066 - doi:10.1007/s001220051387
• Le Thierry d’Ennequin M*, Toupance B*, Robert T, Godelle B, Gouyon PH (1999) Plant domestication: a model for studying the selection of linkage. J-Evol-Biol 12: 1138-1147 - doi:10.1046/j.1420-9101.1999.00115.x
• Tenaillon O*, Toupance B*, Le Nagard H, Taddei F, Godelle B (1999) Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria. Genetics 152: 485-493 - pmid:10353893
• Toupance B, Godelle B, Gouyon PH, Schächter F (1998) A model for antagonistic pleiotropic gene action for mortality and advanced age. Am-J-Hum-Genet 62: 1525-1534 - doi:10.1086/301865 - pmid:9585593
• Taddei F, Radman M, Maynard-Smith J, Toupance B, Gouyon PH, Godelle B (1997) Role of mutator alleles in adaptive evolution. Nature 387: 700-702 - doi:10.1038/42696 - pmid:9192893
• Leibl W, Toupance B, Breton J (1995) Photoelectric characterization of forward electron transfer to iron-sulfur centers in photosystem I. Biochemistry 34: 10237-10244 - doi:10.1021/bi00032a018 - pmid:7640279