QUACH Hélène

PROJET DE RECHERCHE PRINCIPAL

BeeCON - Etude de la variabilité socioculturelle des pratiques de récolte de miel en Indonésie et de leurs effets sur la conservation des abeilles (ANR-23-CE03-0003)

Fonction : co-coordinatrice avec Nicolas Césard
 

PROJETS DE RECHERCHE EN COLLABORATION

Epigender - Influence des normes de genre sur les marqueurs épigénétiques de santé (ANR-22-CE36-0008, coordinatrice Raphaëlle Chaix)

Fonction : partenaire - responsable scientifique

ParisAncientDNA - Etude paléogénomique des populations humaines du Bassin Parisien entre le néolithique et le 17e siècle (ANR-21-CE12-0007, coordinatrice Marie-Claude Marsolier-Kergoat)

Fonction : responsable scientifique et technique

MORTUI - Impact des pandémies passées sur l'évolution de l'homme (ANR-19-CE35-0005, coordinateur Etienne Patin)

Fonction : responsable technique

PUBLICATIONS

O'Neill MB, Quach H, Pothlichet J, Aquino Y, Bisiaux A, Zidane N, Deschamps M, Libri V, Hasan M, Zhang SY, Zhang Q, Matuozzo D, Cobat A, Abel L, Casanova JL, Naffakh N, Rotival M, Quintana-Murci L. Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans (2021). Front Immunol 12:768189. doi: 10.3389/fimmu.2021.768189.

Rotival M, Siddle KJ, Silvert M, Pothlichet J, Quach H, Quintana-Murci L. Population variation in miRNAs and isomiRs and their impact on human immunity to infection (2020). Genome Biol 21(1):187. doi: 10.1186/s13059-020-02098-w.

Rotival M, Quach H, Quintana-Murci L. Defining the genetic and evolutionary architecture of alternative splicing in response to infection (2019). Nat Commun 10(1):1671. doi: 10.1038/s41467-019-09689-7.

Husquin LT, Rotival M, Fagny M, Quach H, Zidane N, McEwen LM, MacIsaac JL, Kobor MS, Aschard H, Patin E, Quintana-Murci L. Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation (2018). Genome Biol 19(1):222. doi: 10.1186/s13059-018-1601-3.

Lopez M, Kousathanas A, Quach H, Harmant C, Mouguiama-Daouda P, Hombert JM, Froment A, Perry GH, Barreiro LB, Verdu P, Patin E, Quintana-Murci L. The demographic history and mutational load of African hunter-gatherers and farmers (2018). Nat Ecol Evol 2(4):721-730. doi: 10.1038/s41559-018-0496-4.

Patin E, Hasan M, Bergstedt J, Rouilly V, Libri V, Urrutia A, Alanio C, Scepanovic P, Hammer C, Jönsson F, Beitz B, Quach H, Lim YW, Hunkapiller J, Zepeda M, Green C, Piasecka B, Leloup C, Rogge L, Huetz F, Peguillet I, Lantz O, Fontes M, Di Santo JP, Thomas S, Fellay J, Duffy D, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium. Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors (2018). Nat Immunol 19(3):302-314. doi: 10.1038/s41590-018-0049-7.

Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium. Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges (2018). Proc Natl Acad Sci USA 115(3):E488-E497. doi: 10.1073/pnas.1714765115.

Laso-Jadart R, Harmant C, Quach H, Zidane N, Tyler-Smith C, Mehdi Q, Ayub Q, Quintana-Murci L, Patin E. The Genetic Legacy of the Indian Ocean Slave Trade: Recent Admixture and Post-admixture Selection in the Makranis of Pakistan (2017). Am J Hum Genet 101(6):977-984. doi: 10.1016/j.ajhg.2017.09.025.

Patin E, Lopez M, Grollemund R, Verdu P, Harmant C, Quach H, Laval G, Perry GH, Barreiro LB, Froment A, Heyer E, Massougbodji A, Fortes-Lima C, Migot-Nabias F, Bellis G, Dugoujon JM, Pereira JB, Fernandes V, Pereira L, Van der Veen L, Mouguiama-Daouda P, Bustamante CD, Hombert JM, Quintana-Murci L. Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America (2017). Science 356(6337):543-546. doi: 10.1126/science.aal1988.

Quach H, Quintana-Murci L. Living in an adaptive world: Genomic dissection of the genus Homo and its immune response (2017). J Exp Med 214(4):877-894. doi: 10.1084/jem.20161942.

Quach H, Rotival M, Pothlichet J, Loh YE, Dannemann M, Zidane N, Laval G, Patin E, Harmant C, Lopez M, Deschamps M, Naffakh N, Duffy D, Coen A, Leroux-Roels G, Clément F, Boland A, Deleuze JF, Kelso J, Albert ML, Quintana-Murci L. Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations (2016). Cell 167(3):643-656.e17. doi: 10.1016/j.cell.2016.09.024.

Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L. The epigenomic landscape of African rainforest hunter-gatherers and farmers (2015). Nat Commun 30;6:10047. doi: 10.1038/ncomms10047.

Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L. The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists (2014). Nat Commun 5:3163. doi: 10.1038/ncomms4163.

Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci L. Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations (2013). Hum Mol Genet 22(23):4829-40. doi: 10.1093/hmg/ddt335.

Vasseur E, Boniotto M, Patin E, Laval G, Quach H, Manry J, Crouau-Roy B, Quintana-Murci L. The evolutionary landscape of cytosolic microbial sensors in humans (2012). Am J Hum Genet 91(1):27-37. doi: 10.1016/j.ajhg.2012.05.008.

Ben-Ali M, Corre B, Manry J, Barreiro LB, Quach H, Boniotto M, Pellegrini S, Quintana-Murci L. Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family (2011). Hum Mutat 32(6):643-52. doi: 10.1002/humu.21486.

Quintana-Murci L, Harmant C, Quach H, Balanovsky O, Zaporozhchenko V, Bormans C, van Helden PD, Hoal EG, Behar DM. Strong maternal Khoisan contribution to the South African coloured population: a case of gender-biased admixture (2010). Am J Hum Genet 86(4):611-20. doi: 10.1016/j.ajhg.2010.02.014.

Barreiro LB, Ben-Ali M, Quach H, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Ragimbeau J, Pellegrini S, Abel L, Casanova JL, Quintana-Murci L. Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense (2009). PLoS Genet 5(7):e1000562. doi: 10.1371/journal.pgen.1000562.

Quach H, Barreiro LB, Laval G, Zidane N, Patin E, Kidd KK, Kidd JR, Bouchier C, Veuille M, Antoniewski C, Quintana-Murci L. Signatures of purifying and local positive selection in human miRNAs (2009). Am J Hum Genet 84(3):316-27. doi: 10.1016/j.ajhg.2009.01.022.

Quintana-Murci L, Quach H, Harmant C, Luca F, Massonnet B, Patin E, Sica L, Mouguiama-Daouda P, Comas D, Tzur S, Balanovsky O, Kidd KK, Kidd JR, van der Veen L, Hombert JM, Gessain A, Verdu P, Froment A, Bahuchet S, Heyer E, Dausset J, Salas A, Behar DM. Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers (2008). Proc Natl Acad Sci USA 105:1596-601. doi: 10.1073/pnas.0711467105.

Barreiro LB, Laval G, Quach H, Patin E, Quintana-Murci L. Natural selection has driven population differentiation in modern humans (2008). Nature Genet 40(3):340-5. doi: 10.1038/ng.78.

Barreiro LB, Quach H, Krahenbuhl J, Khaliq S, Mohyuddin A, Mehdi SQ, Gicquel B, Neyrolles O, Quintana-Murci L. DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated to leprosy in the Pakistani population (2006). Hum Immunol 67(1-2):102-07. doi: 10.1016/j.humimm.2006.02.028.

Duprez R, Hbid O, Afonso P, Quach H, Belloul L, Fajali N, Ismaili N, Benomar H, Hassane Tahri E, Huerre M, Quintana-Murci L, Gessain A. Molecular epidemiology of the HHV-8 K1 gene from Moroccan patients with Kaposi's sarcoma (2006). Virology 353(1):121-32. doi: 10.1016/j.virol.2006.04.026.

Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H, McElreavey K, Helden PD, Hoal EG, Gicquel B, Quintana-Murci L. Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis (2006). PLoS Med 3(2):e20. doi: 10.1371/journal.pmed.0030020.

Durand CM, Kappeler C, Betancur C, Delorme R, Quach H, Goubran-Botros H, Melke J, Nygren G, Chabane N, Bellivier F, Szoke A, Schurhoff F, Rastam M, Anckarsäter H, Gillberg C, Leboyer M, Bourgeron T. Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders (2006). Am J Med Genet B Neuropsychiatr Genet 141B(1):67-70.

Quintana-Murci L, Gal I, Bakhan T, Quach H, Sayar SH, Shiri-Sverdlov R, Baruch RG, McElreavey K, Dagan E, Narod S, Friedman E. The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi Jews (2005). Fam Cancer 4(2):85-8. doi: 10.1007/s10689-004-2101-z.

Bah J, Quach H, Ebstein RP, Segman RH, Melke J, Jamain S, Rietschel M, Modai I, Kanas K, Karni O, Lerer B, Gourion D, Krebs MO, Etain B, Schürhoff F, Szöke A, Leboyer M, Bourgeron T. Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia (2004). Neuroreport 15(12):1987-91. doi: 10.1097/00001756-200408260-00031.

Jamain S, Quach H, Betancur C, Råstam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, Bourgeron T; Paris Autism Research International Sibpair Study. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism (2003). Nature Genet 34(1):27-9. doi: 10.1038/ng1136.

Jamain S, Betancur C, Quach H, Philippe A, Fellous M, Giros B, Gillberg C, Leboyer M, Bourgeron T; Paris Autism Research International Sibpair Study. Linkage and association of the glutamate receptor 6 gene with autism (2002). Mol Psychiatry 7(3):302-10. doi: 10.1038/sj.mp.4000979.

Jamain S, Quach H, Quintana-Murci L, Betancur C, Philippe A, Gillberg C, Sponheim E, Skjeldal OH, Fellous M, Leboyer M, Bourgeron T. Y-chromosome haplogroups in autistic subjects (2002). Mol Psychiatry 7(2):217-19. doi: 10.1038/sj.mp.4000968.

Jamain S, Girondot M, Leroy P, Clergue M, Quach H, Fellous M, Bourgeron T. Transduction of the human gene FAM8A1 by endogenous retrovirus during primate evolution (2001). Genomics 78(1-2):38-45. doi: 10.1006/geno.2001.6642.

Jamain S, Quach H, Fellous M, Bourgeron T. Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia (2001). Genomics 74(1):36-44. doi: 10.1006/geno.2001.6535.